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Associate Director, Medicinal Chemistry REMOTE OPTIONS (Small Molecule)

Company: Autobahn Therapeutics, Inc.
Location: Kansas City
Posted on: January 16, 2022

Job Description:

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company's pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (ANON), a rare genetic disorder. We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders.
We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders. -Autobahn Therapeutics has a deep investor base, anchored by ARCH Venture Partners, and is located in San Diego. For more information, visit www.autobahntx.com.
Key Responsibilities -In this role, the successful candidate will manage internal and external medicinal chemistry efforts of CNS-driven drug discovery programs. This is primarily an office-based position. The role is focused on the generation of novel chemical matter with excellent drug-like properties and partners closely with discovery -biology, translational -sciences, -DMPK, structural biology, and other key functions. Daily activities will include analysis of screening data, compound design, synthetic route planning, scientific direction of synthetic chemistry CROs, and facilitating testing through compound management. Additionally, this role will require regular presentations of rationales, key data, issues, and accomplishments of the chemistry efforts to other members -of -the cross-functional discovery -team and to -the broader organization, as necessary.
Requires occasional travel to San Diego for meetings -Qualifications -

  • Ph.D. in synthetic organic chemistry with --+ years pharmaceutical medicinal chemistry industrial experience or
  • NAS. or B.S. in synthetic organic chemistry with 15+ years pharmaceutical medicinal chemistry industrial experience
  • Experience using biological data, structural information, and computational modeling to design novel drug candidates and directing the advancement of chemical scaffolds from early lead identification to development candidate selection
  • Expert understanding of modern medicinal chemistry concepts along with excellent working knowledge of ligand-protein interactions, conformational and structural analysis methods
  • A deep knowledge of biochemical, ADME, physicochemical, and pharmacological principles allowing for the independent design of drug-like molecules
  • Track record of innovation and impact on programs demonstrated through co- inventorship on patents/applications and authorship of publications in peer-reviewed journals
  • Strong skills in gathering, analyzing, and documenting competitive information from
  • sources such as patents, meetings, and primary literature to guide program strategies
  • Excellent oral and written communication skills, including ability to present the rationale,
  • data, issues, and accomplishments of the team -Attributes
    • Team player with strong interpersonal and communication skills
    • Positive and professional approach with strong time management and organization skills
    • Strong synthetic problem-solving skills with a high level of creativity and productivity -

Keywords: Autobahn Therapeutics, Inc., Kansas City , Associate Director, Medicinal Chemistry REMOTE OPTIONS (Small Molecule), Executive , Kansas City, Kansas

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